Senior Clinical Scientist

About Jade Biosciences

Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an anti-IFN-β monoclonal antibody. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn .

Role Overview

We are seeking a highly motivated and experienced Senior Clinical Scientist to support clinical development programs in nephrology , with a focus on rare or immune-mediated kidney diseases . This individual will play a key role in translating clinical strategy into high-quality execution of late-stage phase clinical trials . This is an exciting opportunity to join a growing biotechnology company where individual contributions have significant impact. The ideal candidate thrives in a fast-paced, collaborative environment, demonstrates strong scientific and operational expertise , and takes ownership of key deliverables. This newly created position will report to the Executive Medical Director of Clinical Development . The role is fully remote and will require periodic travel for investigator meetings, study team meetings, conferences, and other business activities.

Key Responsibilities

Clinical Development and Study Execution

• Serve as the Clinical Scientist for one or more Phase 2 and/or Phase 3 clinical studies.
• Contribute to study design, protocol development, and protocol amendments.
• Develop and review study-related documents including:
• Protocols
• Investigator's Brochures
• Informed Consent Forms
• Clinical study reports
• Study manuals and training materials
• Safety management plans
• Provide scientific oversight throughout study conduct to ensure protocol compliance and data quality.
• Partner closely with Clinical Operations to support study start-up, enrollment, trial execution, and close-out activities.
• Participate in investigator meetings, site training, and scientific discussions with investigators and key opinion leaders.

Data Review and Interpretation

• Lead ongoing data review and medical monitoring activities in collaboration with Medical Monitors.
• Identify clinical trends, protocol deviations, safety signals, and data quality issues.
• Collaborate with Data Management and Biostatistics to develop:
• Data review plans
• Edit check specifications
• Endpoint derivation and analysis plans
• Participate in database lock, data cleaning, and analysis activities.
• Contribute to interpretation of study results and development of key messages.

Regulatory and Documentation Support

• Support preparation of regulatory submissions and agency interactions.
• Assist in development of briefing documents and responses to regulatory questions.
• Ensure study conduct aligns with ICH-GCP, applicable regulations, and company standards.

Cross-Functional Collaboration

• Work effectively across Clinical Development, Clinical Operations, Biometrics, Regulatory, Safety, Medical Affairs, and Medical Writing.
• Drive timelines, track deliverables, and proactively identify and mitigate risks.
• Support governance meetings and preparation of study review materials.

Scientific Communication

• Contribute to abstracts, presentations, manuscripts, and scientific publications.
• Participate in advisory boards, investigator meetings, and key external scientific interactions.
• Maintain awareness of evolving scientific, clinical, and competitive landscapes.

Qualifications

Required

• Advanced degree in life sciences, nursing, pharmacy, public health, or related discipline (PharmD, PhD, MS, MPH, or equivalent).
• Minimum 5–8 years of clinical research experience in the biotechnology, pharmaceutical, or CRO industry.
• Experience supporting Phase 2 and/or Phase 3 clinical trials.
• Strong understanding of clinical trial design, clinical data review, and drug development.
• Working knowledge of ICH-GCP, FDA, EMA, and global regulatory requirements.
• Experience reviewing clinical data and collaborating with biostatistics and data management teams.
• Excellent project management, communication, and organizational skills.
• Ability to work independently and manage multiple priorities in a fast-paced environment.

Preferred

• Experience in nephrology, immunology, inflammation, autoimmune diseases, or rare diseases.
• Experience with global multicenter clinical trials.
• Prior involvement in regulatory submissions and health authority interactions.
• Experience contributing to scientific publications and conference presentations.
• Experience working in a small or emerging biotechnology company.

Skills and Competencies

• Strong scientific and analytical thinking
• Attention to detail with a focus on data quality
• Excellent written and verbal communication skills
• Collaborative and team-oriented mindset
• Ability to influence across functions without direct authority
• Comfortably operating in a highly dynamic, entrepreneurial environment
• Proactive, hands-on, and solution-oriented approach

Position Location

This is a remote role; periodic travel to team and company events is required.

The anticipated salary range for candidates for this role is $175,000 - $190,000 . The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography.