Co-op, LNP Discovery

Company Overview:

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety.

Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA.

Become the next standout single strand!

Job Summary:

Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.

We are looking for a highly motivated and innovative candidate for the role of Co-op, LNP Discovery. This is a fantastic opportunity to make a significant impact as a scientifically motivated self-starter capable of independently conceiving, conducting, and critically analyzing his/her own work with minimal supervision.

Primary Responsibilities:

• Executing formulation related experiments including preparing, optimizing, and characterizing the LNP formulations.
• Carrying out some bioassays for evaluating the LNP formulations.
• Facilitating general lab techniques such as sample preparation, cell culture, and nucleic acid work.
• Working across diverse areas to support the group's research activities in a fast-paced and collaborative environment.

Qualifications:

• On track to graduate with a B.S. or M.S. in Biology, Biochemistry, Bioengineering, or a related discipline.
• Coursework related to dosage forms, drug/gene delivery system, and nanotechnology are desirable.
• Experience with production and analytical characterization of LNP formulation is a big plus.
• Ability to write, edit, and follow standard operating procedures, make careful observations, maintain clear and complete records of lab work.‪

Job Type: Co-op

Hourly Rate: $25 - $28 / hour